Association of Metformin With the Development of Age-Related Macular Degeneration.

ABSTRACT:

Importance

Age-related macular degeneration (AMD) is a leading cause of blindness with no treatment available for early stages. Retrospective studies have shown an association between metformin and reduced risk of AMD.

Objective

To investigate the association between metformin use and age-related macular degeneration (AMD).

Design, setting, and participants

The Diabetes Prevention Program Outcomes Study is a cross-sectional follow-up phase of a large multicenter randomized clinical trial, Diabetes Prevention Program (1996-2001), to investigate the association of treatment with metformin or an intensive lifestyle modification vs placebo with preventing the onset of type 2 diabetes in a population at high risk for developing diabetes. Participants with retinal imaging a

SUBMITTER: Domalpally A 

PROVIDER: S-EPMC9936345 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature