Identification of iron metabolism-related genes as diagnostic signatures in sepsis by blood transcriptomic analysis.
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC9938542 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
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Identification of iron metabolism-related genes as diagnostic signatures in sepsis by blood transcriptomic analysis.
Li Huijun H Wang Xu X Yang Qing Q Cheng Liming L Zeng Hao-Long HL
Open life sciences 20230209 1
Iron metabolism is considered to play the principal role in sepsis, but the key iron metabolism-related genetic signatures are unclear. In this study, we analyzed and identified the genetic signatures related to the iron-metabolism in sepsis by using a bioinformatics analysis of four transcriptomic datasets from the GEO database. A total of 21 differentially expressed iron metabolism-related signatures were identified including 9 transporters, 8 enzymes, and 4 regulatory factors. Among them, lip ...[more]
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