Precision estimates of relative and absolute cerebral blood flow in Alzheimer's disease and cognitively normal individuals.

ABSTRACT: Alzheimer's disease is characterized by regional reductions in cerebral blood flow (CBF). Although the gold standard for measuring CBF is [¹⁵O]H₂O PET, proxies of relative CBF, derived from the early distribution phase of amyloid and tau tracers, have gained attention. The present study assessed precision of [¹⁵O]H₂O derived relative and absolute CBF, and compared precision of these measures with that of (relative) CBF proxies. Dynamic [¹⁵O]H₂O, [¹⁸F]florbetapir and [¹⁸F]flortaucipir PET test-retest (TrT) datasets with eleven, nine and fourteen subjects, respectively, were included. Analyses were performed using an arterial input model and/or a simplified reference tissue model, depending on the data av

SUBMITTER: Heeman F 

PROVIDER: S-EPMC9941867 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature