Dataset Information

Real-World Practice of Gastric Cancer Prevention and Screening Calls for Practical Prediction Models.

ABSTRACT:

Introduction

Some gastric cancer prediction models have been published. Still, the value of these models for application in real-world practice remains unclear. We aim to summarize and appraise modeling studies for gastric cancer risk prediction and identify potential barriers to real-world use.

Methods

This systematic review included studies that developed or validated gastric cancer prediction models in the general population.

Results

A total of 4,223 studies were screened. We included 18 development studies for diagnostic models, 10 for prognostic models, and 1 external validation study. Diagnostic models commonly included biomarkers, such as Helicobacter pylori infection indicator, pepsinogen, hormone, and microRNA. Age, sex, smoking, body mass index, and family history of gastric cancer were frequently used in prognostic models. Most of the models were not validated. Only 25% of models evaluated the calibration. All studies had a high risk of bias, but over half had acceptable applicability. Besides, most studies failed to clearly report the application scenarios of prediction models.

Discussion

Most gastric cancer prediction models showed common shortcomings in methods, validation, and reports. Model developers should further minimize the risk of bias, improve models' applicability, and report targeting application scenarios to promote real-world use.

SUBMITTER: He S

PROVIDER: S-EPMC9944379 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Real-World Practice of Gastric Cancer Prevention and Screening Calls for Practical Prediction Models.

He Siyi S Sun Dianqin D Li He H Cao Maomao M Yu Xinyang X Lei Lin L Peng Ji J Li Jiang J Li Ni N Chen Wanqing W

Clinical and translational gastroenterology 20230201 2

<h4>Introduction</h4>Some gastric cancer prediction models have been published. Still, the value of these models for application in real-world practice remains unclear. We aim to summarize and appraise modeling studies for gastric cancer risk prediction and identify potential barriers to real-world use.<h4>Methods</h4>This systematic review included studies that developed or validated gastric cancer prediction models in the general population.<h4>Results</h4>A total of 4,223 studies were screene ...[more]

PMID: 36413795

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Dataset Information

Real-World Practice of Gastric Cancer Prevention and Screening Calls for Practical Prediction Models.

Introduction

Methods

Results

Discussion

Publications

Real-World Practice of Gastric Cancer Prevention and Screening Calls for Practical Prediction Models.

Similar Datasets

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