Association of systemic inflammatory biomarkers with depression risk: Results from National Health and Nutrition Examination Survey 2005–2018 analyses

ABSTRACT:

Background/Aim

Depression has become a multiple disease worldwide, and is closely related to the systemic inflammatory response.

Methods

Based on the data of the National Health and Nutrition Examination Survey (NHANES), this study included 2,514 depressive and 26,487 non-depressive adults. The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were used to quantify systemic inflammation. The multivariate logistic regression and inverse probability weighting methods were used to analyze the effect size of SII and SIRI on the risk of depression.

Results

After adjusting for all confounders, the above associations of SII and SIRI with depression risk remained significant (SII, OR = 1.02, 95% CI = 1.01 to 1.02, p = 0.001; SIRI, O

SUBMITTER: Li X 

PROVIDER: S-EPMC9945233 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature