Giant proteins in a giant cell: Molecular basis of ultrafast Ca²⁺-dependent cell contraction.

ABSTRACT: The giant single-celled eukaryote, Spirostomum, exhibits one of the fastest movements in the biological world. This ultrafast contraction is dependent on Ca²⁺ rather than ATP and therefore differs to the actin-myosin system in muscle. We obtained the high-quality genome of Spirostomum minus from which we identified the key molecular components of its contractile apparatus, including two major Ca²⁺ binding proteins (Spasmin 1 and 2) and two giant proteins (GSBP1 and GSBP2), which act as the backbone and allow for the binding of hundreds of spasmins. The evidence suggests that the GSBP-spasmin protein complex is the functional unit of the mesh-like contractile fibrillar system, which, coupled with various other subcellular structures, provides the mechanis

SUBMITTER: Zhang J 

PROVIDER: S-EPMC9946354 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature