Longitudinal clinical decline and baseline predictors in progressive supranuclear palsy.

ABSTRACT:

Introduction

Progressive supranuclear palsy (PSP) is associated with several clinical variants defined based on ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction, although little is known about how these features progress over time. We aimed to assess the evolution of these core clinical features across variants and assess baseline clinical and neuroimaging predictors of progression.

Methods

Ninety-three PSP patients were recruited by the Neurodegenerative Research Group, Mayo Clinic, and underwent two visits 1-year apart, with baseline MRI and [¹⁸F]flortaucipir PET. We compared baseline and annualized rates of clinical change on the PSP Rating Scale (total, ocular motor, gait/midline scores) and Montreal Cognitive Assessment, acr

SUBMITTER: Pavone C 

PROVIDER: S-EPMC9946437 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature