Ontology highlight
ABSTRACT:
SUBMITTER: Le Hingrat Q
PROVIDER: S-EPMC9946951 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Le Hingrat Quentin Q Sette Paola P Xu Cuiling C Rahmberg Andrew R AR Tarnus Lilas L Annapureddy Haritha H Kleinman Adam A Brocca-Cofano Egidio E Sivanandham Ranjit R Sivanandham Sindhuja S He Tianyu T Capreri Daniel J DJ Ma Dongzhu D Estes Jacob D JD Brenchley Jason M JM Apetrei Cristian C Pandrea Ivona I
Nature communications 20230222 1
CD4<sup>+</sup> T-cell depletion is a hallmark of HIV infection, leading to impairment of cellular immunity and opportunistic infections, but its contribution to SIV/HIV-associated gut dysfunction is unknown. Chronically SIV-infected African Green Monkeys (AGMs) partially recover mucosal CD4<sup>+</sup> T-cells, maintain gut integrity and do not progress to AIDS. Here we assess the impact of prolonged, antibody-mediated CD4 + T-cell depletion on gut integrity and natural history of SIV infection ...[more]