Delineation of recurrent glioblastoma by whole brain spectroscopic magnetic resonance imaging.

ABSTRACT:

Background

Glioblastoma (GBM) cellularity correlates with whole brain spectroscopic MRI (sMRI) generated relative choline to N-Acetyl-Aspartate ratio (rChoNAA) mapping. In recurrent GBM (rGBM), tumor volume (TV) delineation is challenging and rChoNAA maps may assist with re-RT targeting.

Methods

Fourteen rGBM patients underwent sMRI in a prospective study. Whole brain sMRI was performed to generate rChoNAA maps. TVs were delineated by the union of rChoNAA ratio over 2 (rChoNAA > 2) on sMRI and T1PC. rChoNAA > 2 volumes were compared with multiparametric MRI sequences including T1PC, T2/FLAIR, diffusion-restriction on apparent diffusion coefficient (ADC) maps, and perfusion relative cerebral blood volume (rCBV).

Results

rChoNAA > 2 (mean 27.6 cc, range 6.6-79.1 cc) was

SUBMITTER: Bell JB 

PROVIDER: S-EPMC9948314 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature