Accelerated model-based quantitative diffusion MRI: A feasibility study for musculoskeletal application

ABSTRACT:

Purpose

To develop a model-based reconstruction technique for diffusion quantification based on accelerated two-dimensional echo planar data, obtained with multiple b-weightings. In combination with a dedicated undersampling pattern, acceleration factors above three were proven feasible in a clinical setting.

Methods

The proposed model-based method minimizes a cost function considering the l2-norm of the difference between the Fourier transformation of a synthetic diffusion-model-generated k-space and the measured k-space data. Further regularization is performed by introduction of a total variation (TV) constraint to the cost function. Acceleration is achieved by a non-random undersampling pattern using acceleration factors that correspond to the total number of b-values

SUBMITTER: Hufken T 

PROVIDER: S-EPMC9948881 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature