Obesity aggravates contact hypersensitivity reaction in mice.

ABSTRACT:

Background

Obesity is associated with chronic, low-grade inflammation in tissues and predisposes to various complications, including inflammatory skin diseases. However, the link between obesity and contact hypersensitivity (CHS) is not fully understood.

Objectives

We sought to determine the influence of obesity on T helper 1 (Th1)-mediated CHS.

Methods

The activity/phenotype/cytokine profile of the immune cells was tested in vivo and in vitro. Using quantitative polymerase chain reaction (qPCR) and fecal microbiota transplantation (FMT), we tested the role of a high-fat diet (HFD)-induced gut microbiota (GM) dysbiosis in increasing the effects of CHS.

Results

Exacerbated CHS correlates with an increased inflammation-inducing GM in obese mice. We showed a proin

SUBMITTER: Majewska-Szczepanik M 

PROVIDER: S-EPMC9949724 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature