Peroxiredoxin 2 is required for the redox mediated adaptation to exercise.

ABSTRACT: Exercise generates a site-specific increase in Reactive Oxygen Species (ROS) within muscle that promotes changes in gene transcription and mitochondrial biogenesis, required for the beneficial adaptive response. We demonstrate that Peroxiredoxin 2 (Prdx2), an abundant cytoplasmic 2-Cys peroxiredoxin, is required for the adaptive hormesis response to physiological levels of H₂O₂ in myoblasts and following exercise in C. elegans. A short bolus addition of H₂O₂ increases mitochondrial capacity and improves myogenesis of cultured myoblasts, this beneficial adaptive response was suppressed in myoblasts with decreased expression of cytoplasmic Prdxs. Moreover, a swimming exercise protocol in C. elegans increased mitochondrial content, fitness, survival

SUBMITTER: Xia Q 

PROVIDER: S-EPMC9950660 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature