Association of statin use with outcomes of patients admitted with COVID-19: an analysis of electronic health records using superlearner.

ABSTRACT:

Importance

Statin use prior to hospitalization for Coronavirus Disease 2019 (COVID-19) is hypothesized to improve inpatient outcomes including mortality, but prior findings from large observational studies have been inconsistent, due in part to confounding. Recent advances in statistics, including incorporation of machine learning techniques into augmented inverse probability weighting with targeted maximum likelihood estimation, address baseline covariate imbalance while maximizing statistical efficiency.

Objective

To estimate the association of antecedent statin use with progression to severe inpatient outcomes among patients admitted for COVD-19.

Design, setting and participants

We retrospectively analyzed electronic health records (EHR) from individuals ≥ 40-years

SUBMITTER: Rivera AS 

PROVIDER: S-EPMC9951166 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature