Molecular Characteristics of Toxicity of Acrolein Produced from Spermine.

ABSTRACT: Acrolein (CH₂=CH-CHO), an unsaturated aldehyde produced from spermine, is one of the major contributors to oxidative stress. Acrolein has been found to be more toxic than reactive oxygen species (H₂O₂ and •OH), and it can be easily conjugated with proteins, bringing about changes in nature of the proteins. Acrolein is detoxified by glutathione in cells and was found to be mainly produced from spermine through isolating two cell lines of acrolein-resistant Neuro2a cells. The molecular characteristics of acrolein toxicity and tissue damage elicited by acrolein were investigated. It was found that glyceraldehyde-3-phosphate dehydrogenase (GAPDH); cytoskeleton proteins such as vimentin, actin, α- and β-tubulin proteins; and apolipoprotein B-100 (ApoB100) in LDL

SUBMITTER: Kashiwagi K 

PROVIDER: S-EPMC9952977 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature