Integration of Ultrastructural and Computational Approaches Reveals the Protective Effect of Astaxanthin against BPA-Induced Nephrotoxicity.

ABSTRACT:

Background

Bisphenol A (BPA) is an environmental contaminant that can induce deleterious organ effects. Human Cytochrome P450 CYP2C9 enzyme belongs to the essential xenobiotic-metabolizing enzymes, producing ROS as a byproduct. Astaxanthin (ATX) is a powerful antioxidant that protects organs and tissues from the damaging effects of oxidative stress caused by various diseases.

Aim of the study

This study investigated the possible protective impacts of ATX against BPA-induced nephrotoxicity and its underlying mechanism.

Materials and methods

Kidney tissues were isolated and examined microscopically from control, protected, and unprotected groups of rats to examine the potential protective effect of ATX against nephrotoxicity. Moreover, a molecular dynamic (MD) simulatio

SUBMITTER: A Eid R 

PROVIDER: S-EPMC9953522 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature