Preparation and Evaluation of Thermosensitive Liposomes Encapsulating I-125-Labeled Doxorubicin Derivatives for Auger Electron Therapy.

ABSTRACT: Auger electrons (AEs) are very low-energy electrons emitted by radionuclides such as I-125 (¹²⁵I). This energy is deposited across a small distance (<0.5 μm), resulting in high linear energy transfer that is potent for causing lethal damage to cancer cells. Thus, AE-emitting radiotherapeutic agents have great potential for cancer treatment. In this study, thermosensitive liposomes (TSLs) encapsulating ¹²⁵I-labeled doxorubicin (DOX) derivatives were developed for Auger electron therapy, targeting the DNA of cancer cells. A radioiodinated DOX derivative [¹²⁵I]5 highly accumulated in the nuclei of cancer cells and showed potent cytotoxicity against Colon 26 cancer cells by AEs. Subsequently, [¹²⁵I]5 was loaded into the TSLs with high e

SUBMITTER: Elghobary MEN 

PROVIDER: S-EPMC9962004 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature