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Bioinformatic analysis of the obesity paradox and possible associated factors in colorectal cancer using TCGA cohorts.

ABSTRACT: Colorectal cancer (CRC) is a common malignancy worldwide and the second leading cause of cancer-related deaths. Obesity is an important determinant of CRC incidence; however, obese patients have also shown better long-term survival than non-obese patients, suggesting that the development and progression of CRC are associated with different mechanisms. This study compares the expression of genes, tumor-infiltrating immune cells, and intestinal microbiota between high- and low-body mass index (BMI) patients at the time of CRC diagnosis. The results revealed that high-BMI patients with CRC have better prognosis, higher levels of resting CD4+ T cells, lower levels of T follicular helper cells, and different levels of intratumoral microbiota than low-BMI patients. Our study highlights that tumor-infiltrating immune cells and intratumoral microbe diversity are major features of the obesity paradox in CRC.

SUBMITTER: Lim DM

PROVIDER: S-EPMC9969588 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Bioinformatic analysis of the obesity paradox and possible associated factors in colorectal cancer using TCGA cohorts.

Lim Dong Min DM Lee Hyunsu H Eom Kisang K Kim Yun Hak YH Kim Shin S

Journal of Cancer 20230122 3

Colorectal cancer (CRC) is a common malignancy worldwide and the second leading cause of cancer-related deaths. Obesity is an important determinant of CRC incidence; however, obese patients have also shown better long-term survival than non-obese patients, suggesting that the development and progression of CRC are associated with different mechanisms. This study compares the expression of genes, tumor-infiltrating immune cells, and intestinal microbiota between high- and low-body mass index (BMI ...[more]

PMID: 36860923

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