SERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.

ABSTRACT:

Objective

 Obesity in pregnancy bears unique maternal and fetal risks. Obesity has also been associated with chronic inflammation, including elevated serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Higher serum lipopolysaccharide (LPS) levels have been implicated in driving this inflammation, a phenomenon called metabolic endotoxemia (ME). GLP-2, a proglucagon-derived peptide, is believed to be integral in maintaining the integrity of the intestine in the face of LPS-mediated endotoxemia. We hypothesized that obesity and/or excess weight gain in pregnancy would be associated with an increase in maternal and neonatal markers of ME, as well as GLP-2.

Study design

 Paired maternal and neonatal (cord blood) serum samples (n = 159) were obtained f

SUBMITTER: Kahr MK 

PROVIDER: S-EPMC9970758 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature