Enhanced insulin activity achieved in VDRa/b ablation zebrafish.

ABSTRACT:

Introduction

1α,25-dihydroxyvitamin D3 (1α,25[OH]₂VD₃) is a hormone known for its key roles in calcium absorption and nutrient metabolism. In teleost fishes, 1α,25(OH)₂VD₃ insufficiency causes impaired glucose metabolism and lipid oxidation. However, the cascade and mechanisms of 1α,25(OH)₂VD₃ and the vitamin d receptor (VDR) signaling are unclear.

Results

In this study, two genes (vdra and vdrb) encoding paralogs of VDRs were genetically knocked out in zebrafish. Growth retardation and accumulated visceral adipose tissue have been observed in vdra ^-/-;vdrb ^-/- deficient line. In the liver elevated accumulation of triglycerides and suppressed lipid oxidation we

SUBMITTER: Liu R 

PROVIDER: S-EPMC9972578 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature