A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

We have shown that combined caloric restriction (CR) and aerobic exercise training (AT) improve peak exercise O₂ consumption (VO_2peak), and quality-of-life in older patients with obese heart failure with preserved ejection fraction. However, ≈35% of weight lost during CR+AT was skeletal muscle mass. We examined whether addition of resistance training (RT) to CR+AT would reduce skeletal muscle loss and further improve outcomes.

Methods

This study is a randomized, controlled, single-blind, 20-week trial of RT+CR+AT versus CR+AT in 88 patients with chronic heart failure with preserved ejection fraction and body mass index (BMI) ≥28 kg/m². Outcomes at 20 weeks included the primary outcome (VO_2peak); MRI and dual X-ray absorp

SUBMITTER: Brubaker PH 

PROVIDER: S-EPMC9974606 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature