A macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury.

ABSTRACT: The most common cause of acute kidney injury (AKI) in critically ill patients is sepsis. Kidney macrophages consist of both F4/80^hi and CD11b^hi cells. The role of macrophage subpopulations in septic AKI pathogenesis remains unclear. As F4/80^hi macrophages are reported to contribute to immunomodulation following injury, we hypothesized that selective depletion of F4/80^hi macrophages would worsen septic AKI. F4/80^hi macrophages were depleted via diphtheria toxin injection in CD11cCre(+)/CX3CR1^dtr/wt (F4/80 MKO mice) compared to CD11cCre(-)/CX3CR1^dtr/wt (F4/80 MWT) mice. F4/80 MWT and F4/80 MKO mice were subjected to sham or cecal ligation and puncture to induce sepsis. Compared to F4/80 MWT mice, F4/80 MKO mice disp

SUBMITTER: Privratsky JR 

PROVIDER: S-EPMC9974788 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature