Brain correlates of impaired goal management in bipolar mania.

ABSTRACT:

Background

Although executive impairment has been reported in mania, its brain functional correlates have been relatively little studied. This study examined goal management, believed to be more closely related to executive impairment in daily life than other executive tasks, using a novel functional magnetic resonance imaging (fMRI) paradigm in patients in this illness phase.

Methods

Twenty-one currently manic patients with bipolar disorder and 30 matched healthy controls were scanned while performing the Computerized Multiple Elements Test (CMET). This requires participants to sequentially play four simple games, with transition between games being made either voluntarily (executive condition) or automatically (control condition).

Results

CMET performance was impair

SUBMITTER: Madre M 

PROVIDER: S-EPMC9976001 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature