Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation.

ABSTRACT:

Background & aims

Hepatocyte transplantation has emerged as a possible treatment option for end-stage liver disease. However, an important obstacle to therapeutic success is the low level of engraftment and proliferation of transplanted hepatocytes, which do not survive long enough to exert therapeutic effects. Thus, we aimed to explore the mechanisms of hepatocyte proliferation in vivo and find a way to promote the growth of transplanted hepatocytes.

Methods

Hepatocyte transplantation was performed in Fah ^-/- mice to explore the mechanisms of hepatocyte proliferation in vivo. Guided by in vivo regeneration mechanisms, we identified compounds that promote hepatocyte proliferation in vitro. The in vivo effects of the

SUBMITTER: Jiang M 

PROVIDER: S-EPMC9976449 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature