Plasma proteomics identifies CRTAC1 as a biomarker for osteoarthritis severity and progression.

ABSTRACT:

Objectives

The aim of this study was to identify biomarkers for radiographic OA severity and progression acting within the inflammation and metabolic pathways.

Methods

For 3517 Rotterdam Study participants, 184 plasma protein levels were measured using Olink inflammation and cardiometabolic panels. We studied associations with severity and progression of knee, hip and hand OA and a composite overall OA burden score by multivariable regression models, adjusting for age, sex, cell counts and BMI.

Results

We found 18 significantly associated proteins for overall OA burden, of which 5 stayed significant after multiple testing correction: circulating cartilage acidic protein 1 (CRTAC1), cartilage oligomeric matrix protein (COMP), thrombospondin 4, IL-18 receptor 1 (IL-18R1

SUBMITTER: Szilagyi IA 

PROVIDER: S-EPMC9977119 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature