VSGD-Net: Virtual Staining Guided Melanocyte Detection on Histopathological Images.

ABSTRACT: Detection of melanocytes serves as a critical prerequisite in assessing melanocytic growth patterns when diagnosing melanoma and its precursor lesions on skin biopsy specimens. However, this detection is challenging due to the visual similarity of melanocytes to other cells in routine Hematoxylin and Eosin (H&E) stained images, leading to the failure of current nuclei detection methods. Stains such as Sox10 can mark melanocytes, but they require an additional step and expense and thus are not regularly used in clinical practice. To address these limitations, we introduce VSGD-Net, a novel detection network that learns melanocyte identification through virtual staining from H&E to Sox10. The method takes only routine H&E images during inference, resulting in a promising approach to support

SUBMITTER: Liu K 

PROVIDER: S-EPMC9977454 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature