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Nickel-Catalyzed Amidation of Aryl Alkynyl Acids with Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides.

ABSTRACT: Nickel-catalyzed amidation of aryl alkynyl acids using tetraalkylthiuram disulfides as the amine source is described, affording a series of aryl alkynyl amides in good to excellent yields under mild conditions. This general methodology provides an alternative pathway for the synthesis of useful aryl alkynyl amides in an operationally simple manner, which shows its practical synthetic value in organic synthesis. The mechanism of this transformation was explored through control experiments and DFT calculations.

SUBMITTER: Wang L

PROVIDER: S-EPMC9979367 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Nickel-Catalyzed Amidation of Aryl Alkynyl Acids with Tetraalkylthiuram Disulfides: A Facile Synthesis of Aryl Alkynyl Amides.

Wang Longfei L Qiu Jianhua J Zhang Bohai B Chen Mengqi M Wang Hongxia H Miao Xiaohui X Wu Zhiyong Z Zhao Mingqin M Shen Hongtao H Lai Miao M Shi Xiangdong X

ACS omega 20230215 8

Nickel-catalyzed amidation of aryl alkynyl acids using tetraalkylthiuram disulfides as the amine source is described, affording a series of aryl alkynyl amides in good to excellent yields under mild conditions. This general methodology provides an alternative pathway for the synthesis of useful aryl alkynyl amides in an operationally simple manner, which shows its practical synthetic value in organic synthesis. The mechanism of this transformation was explored through control experiments and DFT ...[more]

PMID: 36872968

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