Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques.

ABSTRACT: ABSTRACTProlonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 10⁵ genome copies per ml plasma, SIV^hi) but not in macaques with low viral loads (< 10⁵, SIV^low). After a second vaccination, the immune responses are robustly enhanced in all uninfected and SIV^low macaques. These responses also show a modera

SUBMITTER: Li P 

PROVIDER: S-EPMC9980405 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature