Development, initial validation, and application of a visual read method for [¹⁸F]MK-6240 tau PET.

ABSTRACT:

Background

The positron emission tomography (PET) radiotracer [¹⁸F]MK-6240 exhibits high specificity for neurofibrillary tangles (NFTs) of tau protein in Alzheimer's disease (AD), high sensitivity to medial temporal and neocortical NFTs, and low within-brain background. Objectives were to develop and validate a reproducible, clinically relevant visual read method supporting [¹⁸F]MK-6240 use to identify and stage AD subjects versus non-AD and controls.

Methods

Five expert readers used their own methods to assess 30 scans of mixed diagnosis (47% cognitively normal, 23% mild cognitive impairment, 20% AD, 10% traumatic brain injury) and provided input regarding regional and global positivity, features influencing assessment, confidence, practicality, and cl

SUBMITTER: Shuping JL 

PROVIDER: S-EPMC9983143 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature