Epigenetics as a versatile regulator of fibrosis.
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ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC9983257 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Epigenetics as a versatile regulator of fibrosis.
Liu Yangdan Y Wen Dongsheng D Ho Chiakang C Yu Li L Zheng Danning D O'Reilly Steven S Gao Ya Y Li Qingfeng Q Zhang Yifan Y
Journal of translational medicine 20230302 1
Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a common cause and outcome of organ failure and even death. Researchers have made many efforts to understand the mechanism of fibrogenesis and to develop therapeutic strategies; yet, the outcome remains unsatisfactory. In recent years, advances in epigenetics, including chromatin remodeling, histone modification, DNA methylation, and noncoding RNA (ncRNA), have provided more insights into the fibrotic process an ...[more]
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