Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in patients with peritoneal surface malignancies (PSM): a prospective single-center registry study.

ABSTRACT:

Purpose

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new, palliative approach for patients with peritoneal surface malignancies (PSMs). Its main goals are to control symptoms and ascites. For this experimental procedure, treatment efficacy and patient safety need to be closely monitored.

Methods

We performed a prospective registry study for patients with PSMs. Cisplatin (C) (7.5 mg/m² body surface) and doxorubicin (D) (1.5 mg/m²) were administered laparoscopically via PIPAC.

Results

Between November 2015 and June 2020, we recorded data from 108 patients and 230 scheduled procedures. Tumor burden, patient fitness, quality of life, operating time and in-hospital stay remained stable over consecutive procedures. We recorded 21 non-a

SUBMITTER: Jansen-Winkeln B 

PROVIDER: S-EPMC9984350 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature