Immunogenicity and protective activity of mRNA vaccine candidates against yellow fever virus in animal models.

ABSTRACT: Despite the success of the widely used attenuated yellow fever (YF) vaccine, its global supply remains a substantial barrier to implementing vaccination campaigns in endemic regions and combating emerging epidemics. In A129 mice and rhesus macaques, we evaluated the immunogenicity and protective activity of messenger RNA (mRNA) vaccine candidates encapsulated in lipid nanoparticles, expressing the pre-membrane and envelope proteins or the non-structural protein 1 of YF virus. Vaccine constructs induced humoral and cell-mediated immune responses in mice, resulting in protection against lethal YF virus infection after passive administration of serum or splenocytes from vaccinated mice. Vaccination of macaques induced sustained high humoral and cellular immune responses for at least 5 months

SUBMITTER: Medina-Magues LG 

PROVIDER: S-EPMC9984760 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature