Facile Display of Homomultivalent Proteins for In Vitro Selections.
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ABSTRACT:
SUBMITTER: Ohoka A
PROVIDER: S-EPMC9985468 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Publications
Facile Display of Homomultivalent Proteins for <i>In Vitro</i> Selections.
Ohoka Ayako A Sarkar Casim A CA
ACS synthetic biology 20230119 2
Low-affinity protein binders are emerging as valuable domains for therapeutic applications because of their higher specificity when presented in multivalent ligands that increase the overall strength and selectivity of receptor binding. <i>De novo</i> discovery of low-affinity binders would be enhanced by the large library sizes attainable with <i>in vitro</i> selection systems, but these platforms generally maximize recovery of high-affinity monovalent binders. Here, we present a facile technol ...[more]
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