Gut Microbiota and Subjective Memory Complaints in Older Women.

ABSTRACT:

Background

Epidemiological studies that investigate alterations in gut microbial composition associated with cognitive dysfunction are limited.

Objective

To examine the association between the gut microbiota and subjective memory complaints (SMCs), a self-reported, validated indicator of cognitive dysfunction.

Methods

In this cross-sectional study of 95 older women selected from the New York University Women's Health Study (NYUWHS), we characterized the gut microbial composition using 16S rRNA gene sequencing. We estimated odds ratio (OR) from beta regression which approximates the ratio of mean relative abundances of individual bacterial taxon from phylum to genus levels by binary (2+ versus < 2) and continuous SMCs.

Results

Women reporting 2 or more SMCs had

SUBMITTER: Wu F 

PROVIDER: S-EPMC9987476 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature