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Modular synthesis of unsaturated aza-heterocycles via copper catalyzed multicomponent cascade reaction.

ABSTRACT: The unsaturated aza-heterocycles such as tetrahydropyridines pose significant applications in both drug discovery and development. However, the methods to construct polyfunctionalized tetrahydropyridines are still limited. Herein, we report a modular synthesis of tetrahydropyridines via copper catalyzed multicomponent radical cascade reaction. The reaction features mild conditions and broad substrate scope. In addition, the reaction could scale up to gram scale with similar yield. A variety of 1,2,5,6-tetrahydropyridines with C3 and C5 substituents could be assembled from simple starting materials. More importantly, the products could serve as versatile intermediate to access various functionalized aza-heterocycles which further demonstrates its utility.

SUBMITTER: Wei S

PROVIDER: S-EPMC9988680 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Modular synthesis of unsaturated aza-heterocycles via copper catalyzed multicomponent cascade reaction.

Wei Siqi S Zhang Guocong G Wang Yahui Y You Mengwei M Wang Yanan Y Zhou Liejin L Zhang Zuxiao Z

iScience 20230209 3

The unsaturated aza-heterocycles such as tetrahydropyridines pose significant applications in both drug discovery and development. However, the methods to construct polyfunctionalized tetrahydropyridines are still limited. Herein, we report a modular synthesis of tetrahydropyridines via copper catalyzed multicomponent radical cascade reaction. The reaction features mild conditions and broad substrate scope. In addition, the reaction could scale up to gram scale with similar yield. A variety of 1 ...[more]

PMID: 36895640

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