Ontology highlight
ABSTRACT:
SUBMITTER: Aloi MS
PROVIDER: S-EPMC9990295 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Aloi Macarena S MS Prater Katherine E KE Sánchez Raymond E A REA Beck Asad A Pathan Jasmine L JL Davidson Stephanie S Wilson Angela A Keene C Dirk CD de la Iglesia Horacio H Jayadev Suman S Garden Gwenn A GA
Journal of neuroinflammation 20230307 1
Alzheimer's Disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the CNS, use microRNAs to rapidly respond to inflammatory signals. MicroRNAs (miRNAs) modulate inflammatory responses in microglia, and miRNA profiles are altered in Alzheimer's disease (AD) patients. Expression of the pro-inflammatory miRNA, miR-155, is increased in the AD brain. However, the role of miR-155 in AD pathog ...[more]