Dataset Information

Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers.

ABSTRACT:

Introduction

Smokers with chronic obstructive pulmonary disease (COPD) are at increased risk of muscle weakness. There are limited data describing weakness in smokers with normal spirometry and preserved ratio-impaired spirometry (PRISm), 2 subgroups at risk of respiratory symptom burden and activity limitations. In this study, we evaluated the associations of 2 weakness measures, sit-to-stand (STS) and handgrip strength (HGS), with clinical outcomes in smokers with COPD, normal spirometry, and PRISm.

Methods

We evaluated 1972 current and former smokers from the COPD Genetic Epidemiology (COPDGene^®) cohort with STS and HGS measurements at their 10-year study visit. Multivariable regression modeling was used to assess associations between weakness measures and the 6-minute walk distance (6MWD) test, the St George's Respiratory Questionnaire (SGRQ), the Short-Form-36 (SF-36), severe exacerbations, and prospective mortality, reported as standardized coefficients (β), odds ratios (ORs), or hazard ratios (HRs).

Results

Compared with HGS, STS was more strongly associated with the 6MWD (β=0.45, p<0.001 versus. β=0.25, p<0.001), SGRQ (β=-0.24, p<0.001 versus β=-0.18, p<0.001), SF-36 Physical Functioning (β=0.36, p<0.001 versus β=0.25, p<0.001), severe exacerbations (OR 0.95, p=0.04 versus OR 0.97, p=0.01), and prospective mortality (HR 0.83, p=0.001 versus HR 0.94, p=0.03). Correlations remained after stratification by spirometric subgroups. Compared with males, females had larger magnitude effect sizes between STS and clinical outcomes.

Conclusions

STS and HGS are easy to perform weakness measures that provide important information about functional performance, health-related quality of life, severe exacerbations, and survival in smokers, regardless of spirometric subgroup. This iterates the importance of screening current and former smokers for weakness in the outpatient setting.

SUBMITTER: Zou RH

PROVIDER: S-EPMC9995230 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers.

Zou Richard H RH Nouraie S Mehdi SM Rossiter Harry B HB McDonald Merry-Lynn ML DeMeo Dawn L DL Mason Stefanie S Washko George R GR Saha Punam K PK Make Barry J BJ Casaburi Richard R Regan Elizabeth A EA Bon Jessica J

Chronic obstructive pulmonary diseases (Miami, Fla.) 20230101 1

<h4>Introduction</h4>Smokers with chronic obstructive pulmonary disease (COPD) are at increased risk of muscle weakness. There are limited data describing weakness in smokers with normal spirometry and preserved ratio-impaired spirometry (PRISm), 2 subgroups at risk of respiratory symptom burden and activity limitations. In this study, we evaluated the associations of 2 weakness measures, sit-to-stand (STS) and handgrip strength (HGS), with clinical outcomes in smokers with COPD, normal spiromet ...[more]

PMID: 36599111

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Dataset Information

Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers.

Introduction

Methods

Results

Conclusions

Publications

Associations Between Muscle Weakness and Clinical Outcomes in Current and Former Smokers.

Similar Datasets

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