Towards reproducible research in recurrent pregnancy loss immunology: Learning from cancer microenvironment deconvolution.

ABSTRACT: The most recent international guidelines regarding recurrent pregnancy loss (RPL) exclude most of the immunological tests recommended for RPL since they do not reach an evidence-based level. Comparisons for metanalysis and systematic reviews are limited by the ambiguity in terms of RPL definition, etiological and risk factors, diagnostic work-up, and treatments applied. Therefore, cohort heterogeneity, the inadequacy of numerosity, and the quality of data confirm a not standardized research quality in the RPL field, especially for immunological background, for which potential research application remains confined in a separate single biological layer. Innovative sequencing technologies and databases have proved to play a significant role in the exploration and validation of cancer research

SUBMITTER: Betti M 

PROVIDER: S-EPMC9996132 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature