Unknown

Dataset Information

0

Chronic critical illness in critically ill COVID-19 patients.


ABSTRACT:

Objectives

To evaluate the presence of chronic critical illness (CCI) in COVID-19 patients and compare clinical characteristics and prognosis of patients with and without CCI admitted to intensive care unit (ICU).

Methods

It was a retrospective, observational study at a university hospital ICU. Patients were accepted as CCI if they had prolonged ICU stay (≥14 days) and got ≥1 score for cardiovascular sequential organ failure assessment (SOFA) score and ≥2 score in other parameters on day 14 of ICU admission which was described as persistent organ dysfunction.

Results

131 of 397 (33%) patients met CCI criteria. CCI patients were older (p = 0.003) and frailer (p < 0.001). Their Acute Physiology and Chronic Health Evaluation (APACHE) II and SOFA scores were higher, PaO2/FiO2 ratio was lower (p < 0.001). Requirement of invasive mechanical ventilation (IMV), steroid use, and septic shock on admission were higher in the CCI group (p < 0.001). CCI patients had higher ICU and hospital mortality than other patients (54.2% vs. 19.9% and 55.7% vs. 22.6%, p < 0.001, respectively). Regression analysis revealed that IMV (OR: 8.40, [5.10-13.83], p < 0.001) and PaO2/FiO2 < 150 on admission (OR: 2.25, [1.36-3.71], p = 0.002) were independent predictors for CCI.

Discussion

One-third of the COVID-19 patients admitted to the ICU were considered as CCI with significantly higher ICU and hospital mortality.

SUBMITTER: Halacli B 

PROVIDER: S-EPMC9996170 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Chronic critical illness in critically ill COVID-19 patients.

Halacli Burcin B   Yildirim Mehmet M   Kaya Esat Kivanc EK   Ulusoydan Ege E   Ersoy Ebru Ortac EO   Topeli Arzu A  

Chronic illness 20230307 1


<h4>Objectives</h4>To evaluate the presence of chronic critical illness (CCI) in COVID-19 patients and compare clinical characteristics and prognosis of patients with and without CCI admitted to intensive care unit (ICU).<h4>Methods</h4>It was a retrospective, observational study at a university hospital ICU. Patients were accepted as CCI if they had prolonged ICU stay (≥14 days) and got ≥1 score for cardiovascular sequential organ failure assessment (SOFA) score and ≥2 score in other parameters  ...[more]

Similar Datasets

2022-02-28 | GSE197259 | GEO
2023-04-29 | GSE206264 | GEO
2024-10-22 | PXD057019 | Pride
2022-02-28 | GSE197258 | GEO
2022-02-28 | GSE197204 | GEO
2021-06-18 | GSE178404 | GEO
2021-07-03 | GSE168400 | GEO
2025-06-18 | GSE300129 | GEO
2021-12-10 | PXD029547 | Pride
| PRJNA809558 | ENA