Abnormal amplitude of low-frequency fluctuation values as a neuroimaging biomarker for major depressive disorder with suicidal attempts in adolescents: A resting-state fMRI and support vector machine analysis.

ABSTRACT:

Objective

Major depressive disorder (MDD) is associated with suicidal attempts (SAs) among adolescents, with suicide being the most common cause of mortality in this age group. This study explored the predictive utility of support vector machine (SVM)-based analyses of amplitude of low-frequency fluctuation (ALFF) results as a neuroimaging biomarker for aiding the diagnosis of MDD with SA in adolescents.

Methods

Resting-state functional magnetic resonance imaging (rs-fMRI) analyses of 71 first-episode, drug-naive adolescent MDD patients with SA and 54 healthy control individuals were conducted. ALFF and SVM methods were used to analyze the imaging data.

Results

Relative to healthy control individuals, adolescent MDD patients with a history of SAs showed reduced ALFF v

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9998935 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature