Ontology highlight
ABSTRACT:
SUBMITTER: Path2Models project
PROVIDER: BMID000000142800 | biostudies-other |
SECONDARY ACCESSION(S): 24180668
REPOSITORIES: biostudies-other

PloS one 20121221 12
Typically, the assembly and closure of a complete bacterial genome requires substantial additional effort spent in a wet lab for gap resolution and genome polishing. Assembly is further confounded by subspecies polymorphism when starting from metagenome sequence data. In this paper, we describe an in silico gap-resolution strategy that can substantially improve assembly. This strategy resolves assembly gaps in scaffolds using pre-assembled contigs, followed by verification with read mapping. It ...[more]