Dataset Information
Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor
Ontology highlight
ABSTRACT:
SUBMITTER: Axel T Brunger
PROVIDER: EMPIAR-11476 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 20230320 13
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) introduced a relatively large number of mutations, including three mutations in the highly conserved heptad repeat 1 (HR1) region of the spike glycoprotein (S) critical for its membrane fusion activity. We show that one of these mutations, N969K induces a substantial displacement in the structure of the heptad repeat 2 (HR2) backbone in the HR1HR2 postfusion bundle. Due to this mutation, fusion-entry peptide inhi ...[more]