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Cryo-electron microscopy of potato virus A


ABSTRACT:

SUBMITTER: Neža Koritnik 

PROVIDER: EMPIAR-12819 | biostudies-other |

REPOSITORIES: biostudies-other

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Species-specific structural adaptation of the potyviral coat protein in virions and virus-like particles.

Koritnik Neža N   Kežar Andreja A   Kavčič Luka L   Žnidarič Magda Tušek MT   Leonardi Adrijana A   De Swarnalok S   Pollari Maija M   Mäkinen Kristiina K   Podobnik Marjetka M  

Communications biology 20260113 1


Potyviruses are the largest group of plant positive-sense single-stranded RNA viruses and represent a major economic burden worldwide. Their coat protein (CP) forms a filamentous, flexible capsid around the genomic RNA. However, information is still lacking on the mechanisms of virion assembly, disassembly and stability, which is central to understanding virus biology and control. Here, we investigate the role of CP in these processes using structural, biochemical and biophysical studies of five  ...[more]

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