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Raw multi-frame images of SUR1/Kir6.2 ATP-sensitive potassium channel in the presence of Aekatperone and ATP

ABSTRACT:

SUBMITTER: Camden M Driggers

PROVIDER: EMPIAR-13517 | biostudies-other |

REPOSITORIES: biostudies-other

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AI-based discovery and cryoEM structural elucidation of a KATP channel pharmacochaperone.

Elsheikh Assmaa A Driggers Camden M CM Truong Ha H HH Yang Zhongying Z Allen John J Henriksen Niel M NM Walczewska-Szewc Katarzyna K Shyng Show-Ling SL

eLife 20250326

Pancreatic KATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the KATP channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used KATP channel inhibitors have been shown to act as pharmacochaperones and restore surface expression of trafficking mutants; however, their therapeutic utility for KATP trafficking-impaired CHI is hindered by high affinity binding, which limits functio ...[more]

PMID: 40135739

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