Waugh2006 - Diabetic Wound Healing - TGF-B Dynamics

ABSTRACT:

This a model from the article:
Macrophage dynamics in diabetic wound dealing.
Waugh HV, Sherratt JA. Bull Math Biol 2006 Jan;68(1):197-207 16794927 ,
Abstract:
Wound healing in diabetes is a complex process, characterised by a chronicinflammation phase. The exact mechanism by which this occurs is not fullyunderstood, and whilst several treatments for healing diabetic wounds exist,very little research has been conducted towards the causes of the extendedinflammation phase. We describe a mathematical model which offers a possibleexplanation for diabetic wound healing in terms of the distribution ofmacrophage phenotypes being altered in the diabetic patient compared to normalwound repair. As a consequence of this, we put forward a suggestion fortreatment based on rectifying the macrophage phenotype imbalance.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Waugh HV, Sherratt JA. (2006) - version=1.0
The original CellML model was created by:
Catherine Lloyd
[e-mail]
The University of Auckland

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1006230011 | biostudies-other |

SECONDARY ACCESSION(S): 16794927

REPOSITORIES: biostudies-other