Wodarz2003 - Immunological Memory

ABSTRACT:

This a model from the article:
Evolution of immunological memory and the regulation of competition betweenpathogens.
Wodarz D. Curr Biol 2003 Sep 16;13(18):1648-52 13678598 ,
Abstract:
Memory is a central characteristic of immune responses. It is defined as anelevated number of specific immune cells that remain after resolution ofinfection and can protect the host against reinfection. The evolution ofimmunological memory is subject to debate. The advantages of memory discussed sofar include protection from reinfection, control of chronic infection, and thetransfer of immune function to the next generation. Mathematical models are usedto identify a new force that can drive the evolution of immunological memory:the duration of memory can regulate the degree of competition between differentpathogens. While a long duration of memory provides lasting protection againstreinfection, it may also allow an inferior pathogen species to persist. This canbe detrimental for the host if the inferior pathogen is more virulent. On theother hand, a shorter duration of memory ensures that an inferior pathogenspecies is excluded. This can be beneficial for the host if the inferiorpathogen is more virulent. Thus, while in the absence of pathogen diversitymemory is always expected to evolve to a long duration, under specificcircumstances, memory can evolve toward shorter durations in the presence ofpathogen diversity.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Wodarz D. (2003) - version=1.0
The original CellML model was created by:
Catherine Lloyd
[e-mail]
The University of Auckland

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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1006230061 | biostudies-other |

SECONDARY ACCESSION(S): 13678598

REPOSITORIES: biostudies-other