Dataset Information
Emiola2016 - Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biosynthesis,
Ontology highlight
ABSTRACT:
SUBMITTER: Akintunde Emiola
PROVIDER: MODEL1601080000 | biostudies-other |
SECONDARY ACCESSION(S): 26929331
REPOSITORIES: biostudies-other
Publications
Crosstalk between the lipopolysaccharide and phospholipid pathways during outer membrane biogenesis in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 20160229 11
The outer membrane of gram-negative bacteria is composed of phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leaflet. LPS is an endotoxin that elicits a strong immune response from humans, and its biosynthesis is in part regulated via degradation of LpxC (EC 3.5.1.108) and WaaA (EC 2.4.99.12/13) enzymes by the protease FtsH (EC 3.4.24.-). Because the synthetic pathways for both molecules are complex, in addition to being produced in strict ratios, we developed a comp ...[more]
