Dataset Information
Tortolina2015 - Multiple signalling pathway associated with colorectal cancer
Ontology highlight
ABSTRACT:
SUBMITTER: Vijayalakshmi Chelliah
PROVIDER: MODEL1601250000 | biostudies-other |
SECONDARY ACCESSION(S): 25671297
REPOSITORIES: biostudies-other
Publications
Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies.
Oncotarget 20150301 7
The interconnected network of pathways downstream of the TGFβ, WNT and EGF-families of receptor ligands play an important role in colorectal cancer pathogenesis.We studied and implemented dynamic simulations of multiple downstream pathways and described the section of the signaling network considered as a Molecular Interaction Map (MIM). Our simulations used Ordinary Differential Equations (ODEs), which involved 447 reactants and their interactions.Starting from an initial "physiologic condition ...[more]
