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Orfeo2010 - Simulating the effects of fondaparinux and Rivaroxaban on thrombin generation

ABSTRACT: Reused mathematical model (Hockin et al., 2002) of blood coagulation simulating the effects of coagulation factor inhibitors, fondaparinux (synthetic heparin) and Rivaroxaban. Fondaparinux (Fpx) simulated to reversibly bind with ATIII before irreversibly binding to Xa, IXa, mIIa, TF:VIIa, Xa:Va and IIa. Rivaroxaban simulated to bind reversibly to Xa and Xa:Va.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Roberts 

PROVIDER: MODEL1807240001 | biostudies-other |

SECONDARY ACCESSION(S): 20492473

REPOSITORIES: biostudies-other

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Anticoagulation by factor Xa inhibitors.

Orfeo T T   Butenas S S   Brummel-Ziedins K E KE   Gissel M M   Mann K G KG  

Journal of thrombosis and haemostasis : JTH 20100521 8

<h4>Background</h4>Therapeutic agents that regulate blood coagulation are critical to the management of thrombotic disorders, with the selective targeting of factor (F) Xa emerging as a promising approach.<h4>Objective</h4>To assess anticoagulant strategies targeting FXa.<h4>Methods</h4>A deterministic computational model of tissue factor (Tf)-initiated thrombin generation and two empirical experimental systems (a synthetic coagulation proteome reconstruction using purified proteins and a whole  ...[more]

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