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Seif2018 - Strain specific Salmonella Genome Scale Models (GEMs)

ABSTRACT: Genome scale metabolic reconstructions of 410 Salmonella strains.

SUBMITTER: Yara Seif 

PROVIDER: MODEL1807280001 | biostudies-other |

SECONDARY ACCESSION(S): 30218022

REPOSITORIES: biostudies-other

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Genome-scale metabolic reconstructions of multiple Salmonella strains reveal serovar-specific metabolic traits.

Seif Yara Y   Kavvas Erol E   Lachance Jean-Christophe JC   Yurkovich James T JT   Nuccio Sean-Paul SP   Fang Xin X   Catoiu Edward E   Raffatellu Manuela M   Palsson Bernhard O BO   Monk Jonathan M JM  

Nature communications 20180914 1

Salmonella strains are traditionally classified into serovars based on their surface antigens. While increasing availability of whole-genome sequences has allowed for more detailed subtyping of strains, links between genotype, serovar, and host remain elusive. Here we reconstruct genome-scale metabolic models for 410 Salmonella strains spanning 64 serovars. Model-predicted growth capabilities in over 530 different environments demonstrate that: (1) the Salmonella accessory metabolic network incl  ...[more]

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