Dataset Information
Simon2019 - NIK-dependent p100 processing into p52, Mass Action, SBML 2v4
Ontology highlight
ABSTRACT: This model represents NIK-dependent p100 processing into p52 with mass action kinetics. While this model shows identical dose-response to the Michaelis-Menten representation, when IkBd degradation is included the dose-response is no longer monotonic in mass action models due to substrate complex competition.
SUBMITTER: Lucian Smith
PROVIDER: MODEL1903280002 | biostudies-other |
SECONDARY ACCESSION(S): 10.1073/pnas.1816000116
REPOSITORIES: biostudies-other
Publications
Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB.
Proceedings of the National Academy of Sciences of the United States of America 20190502 21
Signaling pathways often share molecular components, tying the activity of one pathway to the functioning of another. In the NFκB signaling system, distinct kinases mediate inflammatory and developmental signaling via RelA and RelB, respectively. Although the substrates of the developmental, so-called noncanonical, pathway are induced by inflammatory/canonical signaling, crosstalk is limited. Through dynamical systems modeling, we identified the underlying regulatory mechanism. We found that as ...[more]
